• Preston Lab

    The Preston Lab is located at Royal College of Surgeons in Ireland (RCSI) and is part of the Irish Centre for Vascular Biology and the School of Pharmacy and Biomolecular Sciences.

    Our group aims to develop new therapeutic and diagnostic approaches for treatment of haematological and inflammatory disorders.

    We are particularly interested in the protein C pathway, whose multiple biological roles provide opportunities to engineer new therapeutic agents for haematological and inflammatory disease.

  • LAB NEWS

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  • FUNDING SUPPORT

    Research Funding

    Science Foundation Ireland

    SFI Career Development and COVID-19 Rapid Response Call Awards

    National Children's Research Centre

    Project grant awards

  • Preston Lab

    People

    Roger Preston

    Principal Investigator

    @rogerjspreston rogerpreston@rcsi.ie

    Emily Browne

    Research Assistant

    Gemma Leon

    Postdoc

    Seán McCluskey

    Postdoc

    Aisling Rehill

    PhD student

    Amin Tashakor

    Postdoc

    Johana Tello Velasquez

    Postdoc

  • Preston Lab

    Joining the Lab

    Our lab is keen to recruit motivated scientists with individual funding awards to join our laboratory. Please contact Roger Preston (rogerpreston@rcsi.ie) if interested in applying for funding to join the lab.

     

    Relevant funding opportunities are listed below:

    Wellcome Trust Fellowships

    Marie Skłodowska-Curie Action Individual Fellowships.

    Irish Research Council Postdoctoral Fellowships

    Irish Research Council Postgraduate Scholarship Programme.

  • Lab publications

    Rehill AM, McCluskey S, O'Donnell JS, Dockal M, Preston RJS; iPATH Study Group. Semin Thromb Hemost. 2021 Mar;47(2):183-191. doi: 10.1055/s-0041-1723769. Epub 2021 Feb 26.PMID: 33636749

    Preston RJS, O'Sullivan JM. Semin Thromb Hemost. 2021 Mar;47(2):117-119. doi: 10.1055/s-0041-1723800. Epub 2021 Feb 26.PMID: 33636743

    Preston RJS, O'Sullivan JM. Semin Thromb Hemost. 2021 Mar;47(2):117-119. doi: 10.1055/s-0041-1723800. Epub 2021 Feb 26.PMID: 33636743

    Ward SE, Curley GF, Lavin M, Fogarty H, Karampini E, McEvoy NL, Clarke J, Boylan M, Alalqam R, Worrall AP, Kelly C, de Barra E, Glavey S, Ni Cheallaigh C, Bergin C, Martin-Loeches I, Townsend L, Mallon PW, O'Sullivan JM, O'Donnell JS; Irish COVID-19 Vasculopathy Study (ICVS) Investigators. Br J Haematol. 2021 Feb;192(4):714-719. doi: 10.1111/bjh.17273. Epub 2020 Dec 16.PMID: 33326604

    Rehill AM, Preston RJS. J Thromb Haemost. 2020 Sep;18(9):2123-2125. doi: 10.1111/jth.14987.PMID: 32881335

    O'Sullivan JM, Gonagle DM, Ward SE, Preston RJS, O'Donnell JS. Lancet Haematol. 2020 Aug;7(8):e553-e555. doi: 10.1016/S2352-3026(20)30215-5. Epub 2020 Jun 30.PMID: 32619412

    Gleeson EM, Rehill AM, Willis Fox O, Ni Ainle F, McDonnell CJ, Rushe HJ, McCluskey S, O'Donnell JS, Preston RJS. Blood Adv. 2020 Jun 9;4(11):2404-2408. doi: 10.1182/bloodadvances.2019001316.PMID: 32484855

    Willis Fox O, Preston RJS. J Thromb Haemost. 2020 Jan;18(1):6-16. doi: 10.1111/jth.14643. Epub 2019 Oct 17.PMID: 31549766

    Hughes MM, Hooftman A, Angiari S, Tummala P, Zaslona Z, Runtsch MC, McGettrick AF, Sutton CE, Diskin C, Rooke M, Takahashi S, Sundararaj S, Casarotto MG, Dahlstrom JE, Palsson-McDermott EM, Corr SC, Mills KHG, Preston RJS, Neamati N, Xie Y, Baell JB, Board PG, O'Neill LAJ. Cell Rep. 2019 Oct 1;29(1):151-161.e5. doi: 10.1016/j.celrep.2019.08.072.PMID: 31577945

    O'Donnell JS, O'Sullivan JM, Preston RJS. Br J Haematol. 2019 Jul;186(1):24-36. doi: 10.1111/bjh.15872. Epub 2019 Mar 28.PMID: 30919939

    Preston RJS, O'Sullivan JM, O'Donnell JS. Br J Haematol. 2019 Jul;186(1):13-23. doi: 10.1111/bjh.15869. Epub 2019 Mar 24.PMID: 30906986

    Aguila S, Lavin M, Dalton N, Patmore S, Chion A, Trahan GD, Jones KL, Keenan C, Brophy TM, O'Connell NM, Ryan K, Byrne M, Nolan M, Patel A, Preston RJS, James P, Di Paola J, O'Sullivan JM, O'Donnell JS. Blood. 2019 Apr 4;133(14):1585-1596. doi: 10.1182/blood-2018-09-874636. Epub 2019 Feb 15.PMID: 30770394

    Preston RJS, Lisman T. Semin Thromb Hemost. 2018 Mar;44(2):89-90. doi: 10.1055/s-0037-1612624. Epub 2018 Feb 22.PMID: 29471579

    McDonnell CJ, Soule EE, Walsh PT, O'Donnell JS, Preston RJS. Semin Thromb Hemost. 2018 Mar;44(2):167-175. doi: 10.1055/s-0037-1608910. Epub 2017 Dec 12.PMID: 29232721

    O'Sullivan JM, Preston RJS, Robson T, O'Donnell JS. Semin Thromb Hemost. 2018 Mar;44(2):159-166. doi: 10.1055/s-0037-1607352. Epub 2017 Nov 17.

    Ward SE, O'Sullivan JM, Drakeford C, Aguila S, Jondle CN, Sharma J, Fallon PG, Brophy TM, Preston RJS, Smyth P, Sheils O, Chion A, O'Donnell JS. Blood. 2018 Feb 22;131(8):911-916. doi: 10.1182/blood-2017-06-787853. Epub 2017 Dec 27.PMID: 29282218

    Gleeson EM, McDonnell CJ, Soule EE, Willis Fox O, Rushe H, Rehill A, Smith OP, O'Donnell JS, Preston RJS. J Thromb Haemost. 2017 Nov;15(11):2198-2207. doi: 10.1111/jth.13807. Epub 2017 Sep 21.PMID: 28834159

    Preston RJS, O'Donnell JS. Blood. 2017 Jul 27;130(4):393-395. doi: 10.1182/blood-2017-06-789156.PMID: 28751359

    Lavin M, Aguila S, Schneppenheim S, Dalton N, Jones KL, O'Sullivan JM, O'Connell NM, Ryan K, White B, Byrne M, Rafferty M, Doyle MM, Nolan M, Preston RJS, Budde U, James P, Di Paola J, O'Donnell JS. Blood. 2017 Nov 23;130(21):2344-2353. doi: 10.1182/blood-2017-05-786699. Epub 2017 Sep 15.PMID: 28916584

    Chion A, O'Sullivan JM, Drakeford C, Bergsson G, Dalton N, Aguila S, Ward S, Fallon PG, Brophy TM, Preston RJ, Brady L, Sheils O, Laffan M, McKinnon TA, O'Donnell JS. Blood. 2016 Oct 13;128(15):1959-1968. doi: 10.1182/blood-2016-04-709436. Epub 2016 Aug 23.PMID: 27554083

    Chion A, O'Sullivan JM, Drakeford C, Bergsson G, Dalton N, Aguila S, Ward S, Fallon PG, Brophy TM, Preston RJ, Brady L, Sheils O, Laffan M, McKinnon TA, O'Donnell JS. Blood. 2016 Oct 13;128(15):1959-1968. doi: 10.1182/blood-2016-04-709436. Epub 2016 Aug 23.PMID: 27554083

    O'Sullivan JM, Jenkins PV, Rawley O, Gegenbauer K, Chion A, Lavin M, Byrne B, O'Kennedy R, Preston RJ, Brophy TM, O'Donnell JS. Arterioscler Thromb Vasc Biol. 2016 May;36(5):855-63. doi: 10.1161/ATVBAHA.115.306915. Epub 2016 Mar 24.PMID: 27013611

    O'Sullivan JM, Preston RJ, O'Regan N, O'Donnell JS. Blood. 2016 May 12;127(19):2281-8. doi: 10.1182/blood-2015-11-636464. Epub 2016 Feb 5.PMID: 26851291

    O'Regan N, Moxon C, Gegenbauer K, O'Sullivan JM, Chion A, Smith OP, Preston RJ, Brophy TM, Craig AG, O'Donnell JS. Thromb Haemost. 2016 Apr;115(4):773-80. doi: 10.1160/TH15-10-0796. Epub 2016 Jan 14.

    O'Regan N, Gegenbauer K, O'Sullivan JM, Maleki S, Brophy TM, Dalton N, Chion A, Fallon PG, Grau GE, Budde U, Smith OP, Craig AG, Preston RJ, O'Donnell JS. Blood. 2016 Mar 3;127(9):1192-201. doi: 10.1182/blood-2015-07-654921. Epub 2015 Oct 28.

    Hams E, Bermingham R, Wurlod FA, Hogan AE, O'Shea D, Preston RJ, Rodewald HR, McKenzie AN, Fallon PG. FASEB J. 2016 Feb;30(2):824-35. doi: 10.1096/fj.15-277822. Epub 2015 Oct 21.

    Quinn LM, Drakeford C, O'Donnell JS, Preston RJ. Biochem Soc Trans. 2015 Aug;43(4):691-5. doi: 10.1042/BST20140312. Epub 2015 Aug 3.

    Gleeson EM, Dichiara MG, Salicio A, Quinn LM, Drakeford C, Russell SE, Walsh PT, Orbe J, Hermida J, Smith OP, O'Donnell JS, Montes R, Preston RJ. Blood. 2015 Aug 13;126(7):915-9. doi: 10.1182/blood-2015-03-632877. Epub 2015 Jun 17.

    Kevane B, Donnelly J, D'Alton M, Cooley S, Preston RJ, Ní Ainle F. J Perinat Med. 2014 Jul;42(4):417-25. doi: 10.1515/jpm-2013-0207.

    Gleeson EM, O'Donnell JS, Hams E, Ní Áinle F, Kenny BA, Fallon PG, Preston RJ. Haematologica. 2014 Jan;99(1):185-93. doi: 10.3324/haematol.2013.086918. Epub 2013 Jul 19

    McGrath RT, van den Biggelaar M, Byrne B, O'Sullivan JM, Rawley O, O'Kennedy R, Voorberg J, Preston RJ, O'Donnell JS. Blood. 2013 Dec 12;122(25):4107-10. doi: 10.1182/blood-2013-04-496851. Epub 2013 Oct 8.PMID: 24106205

    Preston RJ, Rawley O, Gleeson EM, O'Donnell JS. Blood. 2013 May 9;121(19):3801-10. doi: 10.1182/blood-2012-10-415000. Epub 2013 Feb 20.

    Gleeson EM, O'Donnell JS, Preston RJ. Cell Mol Life Sci. 2012 Mar;69(5):717-26. doi: 10.1007/s00018-011-0825-0. Epub 2011 Oct 4.

    Ní Ainle F, O'Donnell JS, Johnson JA, Brown L, Gleeson EM, Smith OP, Preston RJ. J Biol Chem. 2011 Jan 14;286(2):1323-30. doi: 10.1074/jbc.M110.159475. Epub 2010 Nov 2.

    McGrath RT, McKinnon TA, Byrne B, O'Kennedy R, Terraube V, McRae E, Preston RJ, Laffan MA, O'Donnell JS. Blood. 2010 Apr 1;115(13):2666-73. doi: 10.1182/blood-2009-09-241547. Epub 2009 Nov 24.

    Bridges DJ, Bunn J, van Mourik JA, Grau G, Preston RJ, Molyneux M, Combes V, O'Donnell JS, de Laat B, Craig A. Blood. 2010 Feb 18;115(7):1472-4. doi: 10.1182/blood-2009-07-235150. Epub 2009 Nov 6.PMID: 19897581

    Ni Ainle F, Preston RJ, Jenkins PV, Nel HJ, Johnson JA, Smith OP, White B, Fallon PG, O'Donnell JS. Blood. 2009 Aug 20;114(8):1658-65. doi: 10.1182/blood-2009-05-222109. Epub 2009 Jun 16.

    Cunningham MS, Preston RJ, O'Donnell JS. Blood Rev. 2009 May;23(3):129-35. doi: 10.1016/j.blre.2008.10.002. Epub 2008 Nov 28.

    Larkin D, de Laat B, Jenkins PV, Bunn J, Craig AG, Terraube V, Preston RJ, Donkor C, Grau GE, van Mourik JA, O'Donnell JS. PLoS Pathog. 2009 Mar;5(3):e1000349. doi: 10.1371/journal.ppat.1000349. Epub 2009 Mar 20.

    Preston RJ, Tran S, Johnson JA, Ní Áinle F, Harmon S, White B, Smith OP, Jenkins PV, Dahlbäck B, O'Donnell JS. J Biol Chem. 2009 Feb 27;284(9):5869-75. doi: 10.1074/jbc.M804703200. Epub 2009 Jan 6.

    Preston RJ, Morse C, Murden SL, Brady SK, O'Donnell JS, Mumford AD. Br J Haematol. 2009 Mar;144(6):946-53. doi: 10.1111/j.1365-2141.2008.07550.x. Epub 2008 Dec 26.PMID: 19133979

    Harmon S*, Preston RJ*, Ni Ainle F, Johnson JA, Cunningham MS, Smith OP, White B, O'Donnell JS. J Biol Chem. 2008 Nov 7;283(45):30531-9. doi: 10.1074/jbc.M802338200. Epub 2008 Sep 8.

    Hochart H, Jenkins PV, Preston RJ, Smith OP, White B, O'Donnell J. Thromb Haemost. 2008 Mar;99(3):570-5. doi: 10.1160/TH07-06-0424.

    Preston RJ, Ajzner E, Razzari C, Karageorgi S, Dua S, Dahlbäck B, Lane DA. J Biol Chem. 2006 Sep 29;281(39):28850-7. doi: 10.1074/jbc.M604966200. Epub 2006 Jul 25.PMID: 16867987

    Persson KE, Stenflo J, Linse S, Stenberg Y, Preston RJ, Lane DA, Rezende SM. Biochemistry. 2006 Sep 5;45(35):10682-9. doi: 10.1021/bi0601151.PMID: 16939220

    Mollica L, Preston RJ, Chion AC, Lees SJ, Collins P, Lewis S, Lane DA. Br J Haematol. 2006 Feb;132(4):487-93. doi: 10.1111/j.1365-2141.2005.05894.x.PMID: 16412021

    Zanardelli S, Crawley JT, Chion CK, Lam JK, Preston RJ, Lane DA. J Biol Chem. 2006 Jan 20;281(3):1555-63. doi: 10.1074/jbc.M508316200. Epub 2005 Oct 12.PMID: 16221672

    Biguzzi E, Razzari C, Lane DA, Castaman G, Cappellari A, Bucciarelli P, Fontana G, Margaglione M, D'Andrea G, Simmonds RE, Rezende SM, Preston R, Prisco D, Faioni EM; Protein S Italian Team. Hum Mutat. 2005 Mar;25(3):259-69. doi: 10.1002/humu.20136.PMID: 15712227  

    Preston RJ, Villegas-Mendez A, Sun YH, Hermida J, Simioni P, Philippou H, Dahlbäck B, Lane DA. FEBS J. 2005 Jan;272(1):97-108. doi: 10.1111/j.1432-1033.2004.04401.x.PMID: 15634335

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    Contact the lab

    prestonlabrcsi@gmail.com

    @rogerjspreston

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